【 abstract 】 objective: to explore the different doses osteolytic ning capsule to the effects of microcirculation hormone osteonecrosis in rabbits. Methods: will pick from January 2012 to January 2015 in the lab during cultivation experiment with healthy rabbits were 32, among them 2 white rabbit set as the control group randomly, 30 white rabbit criterion with the rest of the way "escherichia coli endotoxin and methylprednisolone" preparation into animal model, all for the rabbit, for this model USES 30 animals osteolytic ning capsule treatment, and used in accordance with the different dosage to continue grouping, i.e., the low dose group, middle dose group, high dose group, its daily dosage were 0.5 g/kg, 1.4 g/kg, 4.2 g/kg. After the treatment of the microcirculation indexes were analyzed. Results: the bone erosion ning capsule can improve the concentration of vascular endothelin and nitric oxide, ?